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Antinociceptive Activity of ST36 Acupoint Stimulation by Low-Level Light Therapy (LLLT) in mice

Authors:
Vanessa Erthal
Cristine Hatsuko Baggio
Maria Fernanda de Paula Werner
Percy Nohama

Keywords: Laser acupuncture; antinocicpetion; Zusanli

Abstract:
Laser acupuncture is a modality of low-level light therapy used as an alternative to needling for the past three decades. The ST36 (Zusanli) acupoint is used to treat inflammatory processes, pain and gastrointestinal disturbs. For this reason, the aim of the present study was to evaluate the antinociceptive effect of Laser acupuncture (830 nm, 3 J/cm2) on ST36 acupoint model of acute nociception. To contribute to this understanding was investigated the involvement of adrenergic and adenosinergic systems in the antinociceptive effect of ST36 acupoint stimulation in mice model of acute nociception induced by glutamate (20 µmol per paw). Our results demonstrate that ST36 laser acupuncture inhibited the glutamate-induced nociceptive behavior in 44%. Moreover, the antinociceptive activity of laser irradiation in the glutamate test was significantly reversed by pre-treatment of yohimbine (0.15 mg/kg, i.p.) and caffeine (3 mg/kg, i.p.) but not by prazosin (0.15 mg/kg, i.p). Collectively, these results demonstrated that ST36 photonic stimulus showed antinociceptive effect in acute model of nociception in mice, and that this effect is mediated by activation of the α2 adrenergic and adenosinergic systems.

Pages: 36 to 39

Copyright: Copyright (c) IARIA, 2013

Publication date: March 24, 2013

Published in: conference

ISSN: 2308-4383

ISBN: 978-1-61208-260-8

Location: Lisbon, Portugal

Dates: from March 24, 2013 to March 29, 2013