Home // BIOTECHNO 2013, The Fifth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article
Authors:
Naotaka Nitta
Keywords: flow-mediated dilation; wall shear stress; blood viscosity; ultrasound; endothelium function
Abstract:
For early detection of arteriosclerosis, the evaluation of endothelium function has attracted attention in recent years. Flow-mediated dilation (FMD) is the blood vessel dilation due to the smooth muscle relaxation, which is caused by the effect that the wall shear stress (WSS) on the endothelium induces the nitric oxide (NO) production. Therefore, for accurately evaluating the endothelial function, the quantitative %FMD and WSS must be measured simultaneously. In this study, with the aim of assessing the endothelium function accurately, a novel ultrasound system for simultaneous measurements of %FMD and quantitative WSS is presented. A feature of this system is to combine the %FMD and the WSS obtained by considering the ultrasonically-estimated blood viscosity. The system performance was verified through in vitro experiment using bovine blood and in vivo measurement for healthy volunteers. These results revealed the effectiveness of developed system.
Pages: 40 to 43
Copyright: Copyright (c) IARIA, 2013
Publication date: March 24, 2013
Published in: conference
ISSN: 2308-4383
ISBN: 978-1-61208-260-8
Location: Lisbon, Portugal
Dates: from March 24, 2013 to March 29, 2013