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Analyzing Meiotic DSB Interference by Combining Southern Blotting and Microarray Analysis

Authors:
Hiroshi Toyoizumi
Hideo Tsubouchi

Keywords: meiosis; DSB; Southern blotting; crossover interference; non-homogenous Poisson process; survival analysis.

Abstract:
It is well-known that crossover formation events on a chromosome interfere with each other during meiosis, and this interference affects the distribution of genetic exchanges on a chromosome in sexual reproduction. However, due to the technical difficulties, it is unknown if meiotic double strand break (DSB) formation, the initiating event of meiotic recombination, shows interference. We discuss a method that employs probability theory of survival analysis in conjunction with: chromosome fragment distribution, detected by Southern blotting; and genome-wide DSB

Pages: 44 to 47

Copyright: Copyright (c) IARIA, 2013

Publication date: March 24, 2013

Published in: conference

ISSN: 2308-4383

ISBN: 978-1-61208-260-8

Location: Lisbon, Portugal

Dates: from March 24, 2013 to March 29, 2013