Home // BIOTECHNO 2016, The Eighth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article
Authors:
Andrés Becerra Sandoval
Víctor Andrés Bucheli Guerrero
Pedro Antonio Moreno Tovar
Keywords: virus; host; protein; interaction; short; linear; motif; prediction; eukarya; protein-synthesis; subversion
Abstract:
We argue that virus-host interactions mediated by short linear motifs can be used to analyze common viral attack strategies. In this direction we develop a method for predicting interactions between human protein-synthesis machinery and viral proteins mediated by linear motifs in order to study common protein-synthesis subversion strategies. The method consists in finding viral instances of host linear motifs. We filter these instances by conservation in viral sequences, location in protein disordered regions and scarcity in randomized protein sets. With the filtered motifs we deduce virus-host interactions using the motif-domain associations in the Eukaryotic Linear Motifs (ELM) database. We validate the results against the Linear Motif mediated Protein Interaction Database (LMPID) and obtain a network of interactions between the human protein-synthesis machinery proteins and viruses influenza AH1N1, Dengue1, Ebola, MERS, Rotavirus, WestNile, and Zika.
Pages: 23 to 27
Copyright: Copyright (c) IARIA, 2016
Publication date: June 26, 2016
Published in: conference
ISSN: 2308-4383
ISBN: 978-1-61208-488-6
Location: Lisbon, Portugal
Dates: from June 26, 2016 to June 30, 2016