Home // BIOTECHNO 2021, The Thirteenth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article

Limits of a Glucose-Insulin Model to Investigate Intestinal Absorption in Type 2 Diabetes

Authors:
Danilo Dursoniah
Maxime Folschette
Cedric Lhoussaine
Rebecca Goutchtat
Francois Pattou
Violeta Raverdy

Keywords: Ordinary Differential Equation; Systems Biology; Type 2 Diabetes; Intestinal Glucose Absorption

Abstract:
Abnormal regulation of glucose absorption in the small intestine is an important cause of Type 2 Diabetes (T2D). Even if this hypothesis is clinically well-known, it has not been fundamentally validated yet, mainly due to a lack of reliable metabolic knowledge on the glucose regulation. The main objective of this paper is to test this hypothesis on a highly referenced model composed of ordinary differential equations. This model is tested on an original dataset featuring the observations of obese diabetic patients. It shows its limits to predict our postprandial glycemia and insulinemia time series especially with regard to the crucial complexity of gastro-intestinal regulation.

Pages: 4 to 7

Copyright: Copyright (c) IARIA, 2021

Publication date: May 30, 2021

Published in: conference

ISSN: 2308-4383

ISBN: 978-1-61208-859-4

Location: Valencia, Spain

Dates: from May 30, 2021 to June 3, 2021