Home // BIOTECHNO 2025, The Seventeenth International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies // View article
Authors:
Yulia Einav
Steve Solun
Keywords: Cardiomyopathy, Microarray data, Z-disc
Abstract:
Cardiomyopathies (CM) encompass ischemic and non-ischemic subtypes, with evidence increasingly supporting the involvement of Z-disc-associated genes in their pathogenesis. This study conducted a meta-analysis of ten such genes across six microarray datasets, including 142 samples, to explore their expression patterns in CM. Statistical analyses revealed significantly higher expression levels in CM groups compared to controls, with ischemic CM showing greater variability and heterogeneity than nonischemic CM. Differential expression analysis highlighted substantial downregulation of Filamin C in non ischemic CM and significant upregulation of PDZ and LIM domain proteins in ischemic CM. These findings enhance our understanding of the molecular mechanisms underlying CM and suggest potential therapeutic targets.
Pages: 1 to 2
Copyright: Copyright (c) IARIA, 2025
Publication date: March 9, 2025
Published in: conference
ISSN: 2308-4383
ISBN: 978-1-68558-246-3
Location: Lisbon, Portugal
Dates: from March 9, 2025 to March 13, 2025