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Sono-Contrast Spectroscopy for Cancer Virtual Biopsy in LMIC Settings

Authors:
Yan Yu
Lydia Liao

Keywords: cancer diagnosis; spectroscopy; biopsy; near infrared; focused ultrasound

Abstract:
We present an initiative to adapt, optimize and productize a multimodal breast cancer detection technology, termed “Sono-Contrast Spectroscopy” (SCS), for use in Low- and Middle-Income Countries (LMIC) to facilitate point-of-care early detection of breast cancer. The prototype SCS scanner was developed from proof-of-concept in vivo preclinical research and subsequently through a first-in-human pilot clinical study. Quantitative evaluation with histopathology data from tissue biopsy of the interrogated lesions as ground truth demonstrated that the SCS technique achieved very high discriminating power as measured by sensitivity, specificity and Receiver Operating Characteristics (ROC) analysis; the Area Under the Curve (AUC) ranged from 0.90 to 0.95 in racial/ethnic subgroup analysis, and was equal to 0.91 over the entire study group of 66 subjects. Particularly of relevance to global health applications in the LMIC settings, the SCS technique does not require clinical subspecialty interpretation, is easy to deploy and operate, has no disposable or consumable parts, reports diagnostic results instantaneously, and potentially offers an effective alternative to expensive and invasive large-core vacuum-assisted needle biopsy followed by subspecialty pathology evaluation, all of which may be inaccessible in LMICs. Significant steps towards global health deployment in these settings are outlined.

Pages: 25 to 30

Copyright: Copyright (c) IARIA, 2014

Publication date: August 24, 2014

Published in: conference

ISSN: 2308-4553

ISBN: 978-1-61208-359-9

Location: Rome, Italy

Dates: from August 24, 2014 to August 28, 2014