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An Optimized Research Process for Real-time Drug Response Analysis

Authors:
Matthieu-P. Schapranow
Konrad Klinghammer
Cindy Fähnrich
Hasso Plattner

Keywords: Drug Response Analysis; Genome Data Analysis; Process Integration; In-Memory Database Technology; Precision Medicine; Next-Generation Sequencing.

Abstract:
Latest medical diagnostics, such as genome sequencing, generate increasing amounts of "big medical data". Healthcare providers and medical experts are facing challenges outside of their original field of expertise, such as data processing, data analysis, or data interpretation. Specific software tools optimized for the use by the target audience, as well as systematic processes for data processing and analysis in clinical and research environments are still missing. Our work focuses on the integration of data acquired from latest next-generation sequencing technology, its systematic processing, and instant analysis for researchers and clinicians in the course of precision medicine. We share our research results on developing specific software tools for drug response analysis built on top of our distributed in-memory computing platform for genome data processing. For that, we present our technical foundations, as well as process aspects of integrating and combining heterogeneous data sources, such as genome, patient, and experiment data in the clinical routine.

Pages: 60 to 66

Copyright: Copyright (c) IARIA, 2014

Publication date: August 24, 2014

Published in: conference

ISSN: 2308-4553

ISBN: 978-1-61208-359-9

Location: Rome, Italy

Dates: from August 24, 2014 to August 28, 2014