Home // GLOBAL HEALTH 2014, The Third International Conference on Global Health Challenges // View article
Authors:
Hassan Khachfe
Walaa Darwiche
Stéphane Delanaud
Veronique Bach
Jérôme Gay-Quéheillard
Wiam Ramadan
Wissam Joumaa
Keywords: Pesticide; chlorpyriphos; perinatal life; muscle contractility
Abstract:
Chlorpyriphos (CPF) is a pesticide widely used in agriculture, commercial, and domestic applications. CPF acts in part through inhibition of acetylcholinesterase and thus can produce lasting effects on muscular system. However, the impact of chronic, low-dose exposure of CPF on mammalian muscles is poorly understood. In the present study, we examined in developing rats the effects of in utero and postnatal exposure to CPF, on contractile properties of the diaphragm, a respiratory skeletal muscle, and the digestive smooth muscles of the ileum. Wistar pregnant rats were administered by daily gavage from gestational day 1 to postnatal day 21 (PND21) with vehicle (control) or CPF at different doses: a low dose (1 mg/kg/d) and a high dose (5 mg/kg/d). At PND 21 and 60 the rats were sacrificed and both muscles of the ileum and the diaphragm were sampled for measurement. At PND60, there was a decrease in body weight of rats exposed to 1 mg/kg/d of CPF. Rats exposed to 5 mg/kg/d of CPF showed a lower body weight at all ages studied. In addition, CPF exposure increases the twitch tension of the diaphragm at PND 21 and 60. For the ileum, there was a significant increase in the twitch tension (g/ cm2) of the smooth muscle at PND21 in both groups. In conclusion, chronic prenatal and postnatal exposures to CPF affect the contractility of both the diaphragm and ileal smooth muscles. Further investigations are required to explain these increases in the contractility.
Pages: 89 to 92
Copyright: Copyright (c) IARIA, 2014
Publication date: August 24, 2014
Published in: conference
ISSN: 2308-4553
ISBN: 978-1-61208-359-9
Location: Rome, Italy
Dates: from August 24, 2014 to August 28, 2014