Home // GLOBAL HEALTH 2019, The Eighth International Conference on Global Health Challenges // View article
Authors:
Hiba El Khayat El Sabbouri
Wissam H. Joumaa
Jérôme Gay-Quéheillard
Veronique Bach
Marion Guibourdenche
Narimane Djekkoun
Walaa Darwiche
Wiam Ramadan
Keywords: Chlorpyrifos; high-fat diet; sleep apnea; diaphragm
Abstract:
Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in the world, which acts by inhibiting acetylcholinesterase (AChE). Exposure to this compound is harmful to the respiratory system during in utero and postnatal period. Such perturbations during prenatal and intrauterine life are associated with further diseases at adulthood through fetal programming. Some of these disturbances are linked to food composition and environmental pollutants. The aim of this study is to examine the effects of perigestational exposure to CPF and to a High-Fat Diet (HFD) on the occurrence of sleep apnea in young adult rats. Female rats were exposed for four months before and later during gestation and lactation periods to CPF (1mg/kg/day vs vehicle) with or without HFD. In vivo measurements of sleep apnea were performed by whole-body plethysmography for male pups at post-natal day (PND) 60. Then diaphragm, an essential respiratory muscle, were dissected and used for in vitro measurements of AChE activity assessment. The perigestational exposure to low dose of CPF and/or HFD induced an increase in the sleep apnea index in males at early adulthood, which was associated with a significant decrease in the AchE activity compared to controls. In conclusion, the chronic perigestational exposure to CPF combined with HFD feeding is associated with increased sleep apnea occurrence and reduced AchE activity at early adulthood in rats. Other studies are required to investigate the mechanisms underlying respiratory perturbations during development due to early life perturbations.
Pages: 1 to 3
Copyright: Copyright (c) IARIA, 2019
Publication date: September 22, 2019
Published in: conference
ISSN: 2308-4553
ISBN: 978-1-61208-742-9
Location: Porto, Portugal
Dates: from September 22, 2019 to September 26, 2019