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A New Computational Method of Comparison of DNA Sequences

Authors:
Piotr Waz
Dorota Bielinska-Waz

Keywords: Bioinformatics; Alignment-free methods; Descriptors

Abstract:
A new method of comparison of deoxyribonucleic acid (DNA) sequences, 3D-dynamic representation of DNA sequences, is presented. This method allows for both graphical and numerical similarity/dissimilarity analysis of the sequences. This method is a generalization of our previous method called by us 2D-dynamic representation of DNA sequences. The methodology is taken from physics: the DNA sequence is represented by a set of "material points" in a 3D space. Using this nonstandard approach we have obtained high accuracy: a difference in a single base can be recognized. We can indicate which base it is (cytosine, guanine, adenine, or thymine) and its approximate location in the DNA sequence.

Pages: 5 to 6

Copyright: Copyright (c) IARIA, 2016

Publication date: November 13, 2016

Published in: conference

ISSN: 2308-4529

ISBN: 978-1-61208-513-5

Location: Barcelona, Spain

Dates: from November 13, 2016 to November 17, 2016