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DNA Lattice Nanostructures as Biointerface Materials for Electrochemical Biosensor Studies

Authors:
Murugan Veerapandian
Chang-Hyun Jang
Guie-Sam Lim
Sung Ha Park
Min-Ho Lee
Kyusik Yun

Keywords: DNA lattice Biosensor nanobiocomposite

Abstract:
We demonstrate the use of well designed artificial DNA lattices as active biointerface material for electrochemical biosensing. Gold-PCB electrodes were modified with metalloid-polymer nanocomposite in presence/absence of DNA nanostructures and then characterized for its electrochemical response toward antigen, bovine serum albumin (BSA) and antibody, anti-bovine serum albumin (anit-BSA) interaction. The surface chemical modifications were achieved by utilization of suitable alkane dithiol and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride/N-Hydroxysuccinimde (EDC/NHS) coupling reaction, respectively. Furthermore, UV-visible spectral and Field Emission-Scanning Electron Microscope (FE-SEM) studies ensured the immobilization and morphological characteristics of the designed nanobiocomposite biosensor

Pages: 63 to 66

Copyright: Copyright (c) IARIA, 2011

Publication date: August 21, 2011

Published in: conference

ISSN: 2308-3530

ISBN: 978-1-61208-151-9

Location: Nice/Saint Laurent du Var, France

Dates: from August 21, 2011 to August 27, 2011