Home // ICQNM 2011, The Fifth International Conference on Quantum, Nano and Micro Technologies // View article

The Radiobiological Effect of the TiO2 – Cyclodextrin Suspension

Authors:
Mihaela Corneanu
Gabriel Corneanu
Aurel Ardelean
Carmen Lazău
Ioan Grozescu
Nicoleta G. Hădărugă
Daniel I. Hădărugă
Lucian Barbu-Tudoran

Keywords: TiO2-Au, TiO2-Fe, cyclodextrin, chromosome mutations.

Abstract:
The effect of a TiO2 nanoparticle suspension (4 mg in 5 ml distilled water) doped or not with gold or iron, complexed or not with α- or β-cyclodextrin, on the mitotic division was studied. The treatment was performed in the M cellular mitotic cycle phase, in the meristematic tissue of Nigella damascena radicels, being analyzed the cytogenetic modifications. The cyclodextrin type and the ratio between cyclodextrin and titanium dioxide affect the percentage of normal cells and the chromosome aberration type. The TiO2 complexed with α-cyclodextrin did not facilitate the reunion of the chromosome broken ends (absence of bridges in anaphase and in telophase). The titanium dioxide doped with iron, complexed with α- or β-cyclodextrin, also reduced the percentage of reunion of the broken ends of the chromosomes. These findings suggest the possibility of using doped or undoped TiO2, complexed with α-cyclodextrin, in the anticarcinogen therapy.

Pages: 77 to 82

Copyright: Copyright (c) IARIA, 2011

Publication date: August 21, 2011

Published in: conference

ISSN: 2308-3530

ISBN: 978-1-61208-151-9

Location: Nice/Saint Laurent du Var, France

Dates: from August 21, 2011 to August 27, 2011