Home // ICQNM 2012 , The Sixth International Conference on Quantum, Nano and Micro Technologies // View article
Authors:
Alexander Zhbanov
Sung Yang
Keywords: blood conductivity; erythrocyte sedimentation rate (ESR); aggregation; particle dynamic model (PDM)
Abstract:
The mechanisms influencing the erythrocyte sedimentation and aggregation still remain unclear despite considerable research effort. In this study, we determined the erythrocyte sedimentation rate (ESR) by measuring the electrical conductivity of blood in a miniature chamber with two planar electrodes on the bottom. As the red blood cells settle towards the bottom, the hematocrit (HCT) or erythrocyte volume fraction increases continuously with the time in the lower part of volume. The measured conductivity of blood in the chamber slightly increased during the first minute of observation and then decreased for more than 1.5 h. The dielectric theory was applied to determine the effective conductivity of blood. We have shown the increase of blood conductivity due to aggregation by both experimentally and theoretically. We have investigated the ESR at different HCT levels by using experimentally measured decreasing of blood conductance with time. A particle dynamic model (PDM) was developed to elucidate the relationship between the microfluidic interaction of red blood cells (RBCs) and macroscopic ESR tests. We estimated the initial velocity and acceleration of erythrocytes and completion time of sedimentation.
Pages: 18 to 24
Copyright: Copyright (c) IARIA, 2012
Publication date: August 19, 2012
Published in: conference
ISSN: 2308-3530
ISBN: 978-1-61208-214-1
Location: Rome, Italy
Dates: from August 19, 2012 to August 24, 2012