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Challenges in Modeling Delayed Erosion due to Degradation of Novel Polyanhydride Biomaterials

Authors:
Vladimir Privman
Sergii Domanskyi
Katie Poetz
Devon Shipp

Keywords: biomaterials; cross-linked polyanhydrides; erosion; hydrolysis; rate equations

Abstract:
The long induction period of degradation proceeding without a noticeable mass loss was found in the recent experiments on highly cross-linked photopolymerized polyanhydrides. In order to model the observed phenomenon, we describe the kinetics of several processes such as the intake of water followed by the hydrolytic degradation of the cross-linked polyanhydride matrix. We survey the model and experimental data fitting, which suggest that the long induction interval is caused by the nonlinear dependence of the degradation rates on the local water concentration in the material, suggesting a breakdown of the standard rate-equation approach.

Pages: 10 to 15

Copyright: Copyright (c) IARIA, 2015

Publication date: August 23, 2015

Published in: conference

ISSN: 2308-3530

ISBN: 978-1-61208-431-2

Location: Venice, Italy

Dates: from August 23, 2015 to August 28, 2015