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Agent-based Modelling and Simulation of Insulin-Glucose Subsystem

Authors:
Sebastian Meszyński
Roger G. Nyberg
Siril Yella

Keywords: multi-agent system; normoglycemia; diabetes mellitus; Stolwijk-Hardy model.

Abstract:
Mathematical analytical modeling and computer simulation of the physiological system is a complex problem with great number of variables and equations. The objective of this research is to describe the insulin-glucose subsystem using multi-agent modeling based on intelligence agents. Such an approach makes the modeling process easier and clearer to understand; moreover, new agents can be added or removed more easily to any investigations. The Stolwijk-Hardy mathematical model is used in two ways firstly by simulating the analytical model and secondly by dividing up the same model into several agents in a multiagent system. In the proposed approach a multi-agent system was used to build a model for glycemic homeostasis. Agents were used to represent the selected elements of the human body that play an active part in this process. The experiments conducted show that the multi-agent model has good temporal stability with the implemented behaviors, and good reproducibility and stability of the results. It has also shown that no matter what the order of communication between agents, the value of the result of the simulation was not affected. The results obtained from using the framework of multi-agent system actions were consistent with the results obtained with insulin-glucose models using analytical modeling.

Pages: 63 to 68

Copyright: Copyright (c) IARIA, 2016

Publication date: November 13, 2016

Published in: conference

ISSN: 2308-4065

ISBN: 978-1-61208-518-0

Location: Barcelona, Spain

Dates: from November 13, 2016 to November 17, 2016