Home // International Journal On Advances in Life Sciences, volume 1, number 1, 2009 // View article

Porphyrin – Cis-Platin drug system for HeLa cells photodynamic treatment

Authors:
Rodica-Mariana Ion
Luciana Maresca
Danilo Migoni
Francesco P. Fanizzi

Keywords: Photodynamic therapy, HeLa cells, singlet oxygen, TSPP, Cis-Pt

Abstract:
Photodynamic therapy (PDT) is a clinical approach that use light-activated drugs for the treatment of different kind of tumor tissues. HeLa tumor cells, as an experimental model for study the new biomedical concept of associated PDT with 5,10,15,20-sulphonato-phenyl-porphyrin (TSPP) and an antitumor agent – cisplatin (CisPt), yielded to an enhanced effect on the suppression of tumor cells in vitro. The ultrastructure changes of cells caused by the action of the new concept and laser irradiation were analyzed, putting into evidence a linear survival curves, by the linear quadratic model. The ultrastructural morphologic aspect of the HeLa cells phototreated with TSPP reinforces the results that a great number of cells with plasma membrane damage, characteristics of irreversible cellular lesions were observed.

Pages: 36 to 45

Copyright: Copyright (c) to authors, 2009. Used with permission.

Publication date: June 7, 2009

Published in: journal

ISSN: 1942-2660