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Ability of Acoustic Sensor Devices for Medical Analysis

Authors:
Thomas Rösel
Achim Voigt
Friederike J. Gruhl

Keywords: SAW biosensors; array; point-of-care; cancer diagnosis

Abstract:
There is an increasing demand to monitor course of disease or therapy success of certain diseases via determining concentrations of specific protein markers in blood. For such biomedical applications implying the detection of multiple proteins a cost-effective and rapid analysis system with small sample consumption is required. Biosensor packaging is a useful means to interface the biosensor with the surroundings while ensuring its integrity and performance. We recently developed surface acoustic wave (SAW) biosensor chips, which allow the label-free, sensitive and cost-effective detection of proteins. For that, single SAW devices first are embedded in polymer housings, however, the sensitive sensor area still remains accessible for surface modification. The sensor surface is modified with capture molecules binding specifically to the analyte. Unspecific binding reactions are prevented via intermediate hydrogel layers, such as dextran. Advantages of those SAW biosensor chips are simple handling, low consumption of chemicals used in the coating process and enabling parallel analysis of multiple analytes in one sample. Hence, when applying biosensor surface modifications to a packaging, it is essential that both the effect on the housing and the impact on the biosensor signal response in a subsequent assay are investigated. Our housed SAW chips enable a user-friendly, easy and rapid way to detect different clinical analytes.

Pages: 1 to 4

Copyright: Copyright (c) IARIA, 2012

Publication date: August 19, 2012

Published in: conference

ISSN: 2308-3514

ISBN: 978-1-61208-208-0

Location: Rome, Italy

Dates: from August 19, 2012 to August 24, 2012