Molecular cages for biological applications

Vicente Martí Centelles current research interests focuses on supramolecular systems based on molecular cages for advancing the field of cancer therapy. The project will develop molecular cages with tailored properties for biological applications. The project is funded by the Plan Gen-T: Generació Talent from the local goverment Generalitat Valenciana (Vicente Martí-Centelles page at Plan Gen-T: Generació Talent, Generalitat Valenciana)

In this research line, we aim to develop molecular cage systems to encapsulate drugs for biological applications, for example in cancer therapy. To achieve this ambitious goal we focus on the cage design, starting from the geometry of the building blocks to achieve the desired cage geometry.

Resarch Team

PI: Dr. Vicente Martí-Centelles

Dr. V. Martí-Centelles graduated in Chemistry with honors in 2007 (Univ. Jaume I, Spain). He got a Spanish Ministry of Education grant to develop his PhD on new pseudopeptidic macrocyclic hosts for molecular recognition under the supervision of Profs. S.V. Luis and. M.I. Burguete at Univ. Jaume I with two research stays with C. Cativiela (Univ. Zaragoza) and R. Vilar (Imperial College London). He received his PhD with honors in 2012. He got a postdoctoral grant from the Generalitat Valenciana in 2013 to work at Univ. Jaume I (Prof. S.V. Luis), Oxford Univ. (Prof. P.D. Beer) and the company Biotica (Legionella detection). Then he joined the Paul Lusby research group at Univ. of Edinburgh in 2015. In October 2018 he moved to Univ. Bordeaux / CNRS to work in the Nathan McClenaghan research group as a Marie Curie fellow. In 2020 Dr. Martí obtained a CIDEGENT Distinguished researcher from Generalitat Valenciana to develop his own project on molecular cages for cancer therapy as principal investigator at Instituto de Reconocimiento Molecular y Desarrollo Tecnologico (IDM), Universidad Politécnica de Valencia.

Researcher: Giovanni Montà-González

Giovanni Montà-González graduated in Chemistry in 2018 (Univ. La Laguna, Spain) after defending his Degree Thesis named "Synthesis of indolizidinones via hetero-Diels-Alder reaction" under the supervision of Profs. M.M. Afonso-Rodríguez and J.A. Palenzuela-López. In 2019 he studied a MSc in Organic Chemistry (Univ. Valencia, Spain) and developed his Master Thesis titled "Preparation of a new haptenic derivative for the mycotoxin Alternariol" under the supervision of Profs. C. Agulló-Blanes and A. Abad-Somovilla. Afterwards, he joined the group of Prof. Abad and worked in the development of new immunoanalytical assays for the detection of different mycotoxins (zearalenone and deoxynivalenol) in food. In 2021 he started his PhD studies under the supervision of Dr. V. Martí-Centelles developing Organic Molecular Cages as containers for anticancer drugs.




Infrastructure

Our research is developed at the laboratories of the Interuniversity Institute for Molecular Recognition and Technological Development located at Universitat Politècnica de València that has all the facilities to develop synthetic chemistry (lab space equipped with fumehoods, NMR, UV-Vis, fluorimeter, TGA, RX, etc.). Additionally, the research group has access as internal users to different institutions for further facilities and equipment. This includes advanced NMR, microscopy, cell culture, etc.

The Interuniversity Institute for Molecular Recognition and Technological Development was created by the Valencian Government (IDM) was created in 2015 as an Institute of Interdisciplinary Research between the Universitat Politècnica de València and the Universitat de València.

Work with us

Prospective PhD and postdoctoral researchers are welcome to contact Dr. V. Martí-Centelles by e-mail for further information and how to apply. At the moment we are looking for candidates interested in applying to a Marie Sklodowska-Curie Actions Postdoctoral Fellowships 2021 (MSCA-PF previously MSCA-IF) developing molecular cages integrating chemisrty and biology EURAXESS Hosting Offer https://euraxess.ec.europa.eu/jobs/hosting/call-candidates-interested-applying-marie-sk%C5%82odowska-curie-actions-postdoctoral

Funding

Plan Gen-T: Generació Talent, Generalitat Valenciana

GVA GenT

Proyectos de I+D+i 2020 Angencia estatal de investigación y Ministerio de Ciencia e Innovacion

angencia estatal de investigacion Ministerio de Ciencia e Innovacion